Two per cent alcoholic chlorhexidine versus alcoholic five per cent povidone-iodine for the prevention of perineural catheter colonisation: The CHLOVEPI randomised, controlled trial

Multimodal analgesia, including a regional technique using perineural catheters (PNCs), is recommended for the treatment of moderate-to-severe acute postoperative pain. Perineural are at risk bacterial colonisation. In this study, we compared cutaneous antiseptic efficacy 2% alcoholic chlorhexidine and povidone-iodine-alcohol preventing colonisation PNCs in orthopaedic surgery. We performed randomised, controlled trial, comparing two antisepsis strategies, one based on other povidone-iodine-5% alcohol, placed before The primary endpoint was incidence catheter (threshold > 1000 colony-forming units/ml). secondary endpoints were catheter-related infections adverse effects solutions. From November 2016 to May 2018, included 113 patients study. use associated with lower (15.5% (n = 9) versus 32.7% 18); OR: 0.28 [0.09-0.77], p 0.01). No or solutions observed either group. factors duration ≥ 3 days (p 0.04) obesity 0.005). most frequently identified bacterium Staphylococcus epidermidis. Skin disinfection decreases rates catheters.